From the home page, users can launch simple or complex searches and browse high-throughput data sets by disease, tissue or cell line. The interface is designed for clarity and ease of navigation. It encompasses 1,30,000 non-redundant modification sites, primarily phosphorylation, ubiquitinylation and acetylation.
Our findings indicate that host genetics influence the composition of the human gut microbiome and can do so in ways that impact host metabolism.read more read lessĪbstract: PhosphoSitePlus () is an open, comprehensive, manually curated and interactive resource for studying experimentally observed post-translational modifications, primarily of human and mouse proteins. minuta amendment reduced weight gain and altered the microbiome of recipient mice. An obese-associated microbiome was amended with Christensenella minuta, a cultured member of the Christensenellaceae, and transplanted to germ-free mice. Furthermore, Christensenellaceae and its partners were enriched in individuals with low body mass index (BMI). The most heritable taxon, the family Christensenellaceae, formed a co-occurrence network with other heritable Bacteria and with methanogenic Archaea. We identified many microbial taxa whose abundances were influenced by host genetics. Here, we compared microbiotas across >1,000 fecal samples obtained from the TwinsUK population, including 416 twin pairs. However, whether host genetic variation shapes the gut microbiome and interacts with it to affect host phenotype is unclear. Combined with copy number variant (CNV) data, these results indicate extreme locus heterogeneity but also provide a target for future discovery, diagnostics and therapeutics.read more read lessĪbstract: Host genetics and the gut microbiome can both influence metabolic phenotypes. Mutation screening of six candidate genes in 1,703 ASD probands identified additional de novo, protein-altering mutations in GRIN2B, LAMC3 and SCN1A. In proband exomes, recurrent protein-altering mutations were observed in two genes: CHD8 and NTNG1. Moreover, 39% (49 of 126) of the most severe or disruptive de novo mutations map to a highly interconnected β-catenin/chromatin remodelling protein network ranked significantly for autism candidate genes. Here we show that de novo point mutations are overwhelmingly paternal in origin (4:1 bias) and positively correlated with paternal age, consistent with the modest increased risk for children of older fathers to develop ASD.
Additionally, we also sequenced the exomes of 50 unaffected siblings corresponding to these new (n = 31) and previously reported trios (n = 19), for a total of 677 individual exomes from 209 families. Under the hypothesis that de novo mutations underlie a substantial fraction of the risk for developing ASD in families with no previous history of ASD or related phenotypes-so-called sporadic or simplex families-we sequenced all coding regions of the genome (the exome) for parent-child trios exhibiting sporadic ASD, including 189 new trios and 20 that were previously reported. Ībstract: It is well established that autism spectrum disorders (ASD) have a strong genetic component however, for at least 70% of cases, the underlying genetic cause is unknown.
#Cytoscape 2.8 software#
The software is also available from the Bio-Linux package repository at.
#Cytoscape 2.8 download#
Geneious Basic represents an ideal platform for the bioinformatics community to leverage existing components and to integrate their own specific requirements for the discovery, analysis and visualization of biological data.Īvailability and implementation: Binaries and public API freely available for download at, implemented in Java and supported on Linux, Apple OSX and MS Windows. The result is an increase in the speed and quality of development of computation tools for the life sciences, due to the functionality and graphical user interface available to the developer through the public API. One key contribution to researchers in the life sciences is the Geneious public application programming interface (API) that affords the ability to leverage the existing framework of the Geneious Basic software platform for virtually unlimited extension and customization. It integrates numerous industry-standard discovery analysis tools, with interactive visualizations to generate publication-ready images. Geneious Basic has been designed to be an easy-to-use and flexible desktop software application framework for the organization and analysis of biological data, with a focus on molecular sequences and related data types. Abstract: Summary: The two main functions of bioinformatics are the organization and analysis of biological data using computational resources.
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